Al Ratrout JT1, Al Nazer N1, Ansari NA2
1Department of Dermatology, Qatif Central Hospital, Kingdom of Saudia Arabia
2Departments of Pathology, Bahrain Defence Force Hospital and Royal College of Surgeons in Ireland Kingdom of Bahrain
Correspondence to: Ansari NA, Departments of Pathology, Bahrain Defence Force Hospital and Royal College of Surgeons in Ireland Kingdom of Bahrain.
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Copyright © 2015 Scientific & Academic Publishing. All Rights Reserved.
Abstract
Lichen striatus is a not uncommon linear, self-limited skin eruption in children of unknown aetiology. It rarely affect adults, and is characterized byabrupt onset of pink, tan or hypopigmented small coalescent papules distributed in a linear configuration following Blaschko's lines usually on the extremities or around the trunk, and on the face in 10% of cases. The main differential diagnoses are lichen nitidus, inflammatory linear verrucous epidermal nevus (ILVEN), linear morphea and lichen planus. Here we describe a case of an adult woman with itchy linear erythematous violaceous tiny papules with atrophy on the right side of the neck and face, diagnosed as lichen striatus on the basis of clinical and histopathological features. The unusual findings and diagnostic challenge are discussed.
Keywords:
Lichen striatus
Cite this paper: Al Ratrout JT, Al Nazer N, Ansari NA, Lichen Striatus in an Adult Female, Journal of Health Science, Vol. 5 No. 3A, 2015, pp. 14-16. doi: 10.5923/s.health.201501.05.
1. Introduction
Lichen striatus (LS) is an uncommon, self-limiting, linear dermatosis, which usually affects children, especially girls, between 5-15 years of age [1]. Rarer in adults, its incidence is slightly higher in women [2-4]. The cause is unknown, but it is considered by many authors as a manifestation of mosaicism, characterized by the presence of clones of genetically abnormal epithelial cells that, through a precipitating event, can be recognized by the immune system and induce the affected skin to generate an inflammatory cell mediated response [5, 6].There is an association between atopy and LS, which may contribute to its pathogenesis. Multiple studies report an increased incidence of LS in those with family history of atopy (asthma, allergic rhinitis, atopic dermatitis) [7], and it has also been suggested that the altered immune status of these patients might act as a predisposing factor to trigger the process. Trauma, pregnancy and drugs are also reported as precipitating factors [8, 9]. The diagnosis is essentially clinical in children but can be difficult in adults because of its rarity, so histopathological confirmation is needed especially in unusual sites such as the face.Here we report a female with 6 months history of severe itchy rash on the chin immediately after delivery. Histopathology confirmed the clinical diagnosis of lichen striatus.
2. Case Report
A 38 year old female presented with 6 months history of itchy tiny erythematous papules over the chin extending to the right side of the neck in linear arrangement, becoming flatter with atrophy with progression (Figure 1).![](image/10.5923.s.health.201501.05_001.gif) | Figure 1. Atrophied erythematous papules over the chin extending to the right side of the neck in linear arrangement |
There was no history of similar illness in the family or personal history of atopy, medical illness or drug intake. FBC, U&E, and autoimmune serology were all within normal limits. On clinical examination there were violaceous to darkly pigmented tiny papules with atrophy distributed in the right side of the chin and submandibular region. Hair, nails, mucous membranes and genitalia were unremarkable.Histolopathology showed a lichenoid/interface lymphohistiocytic infiltrate, band-like in places. There was basal epidermal degeneration with colloid bodies and melanin incontinence. Focally the basal degeneration had led to subepidermal cleft formation. There was a notable deep component to the inflammatory infiltrate with perivascular and perieccrine inflammation in the mid/deep dermis. (Figures 2-5)![](image/10.5923.s.health.201501.05_002.gif) | Figure 2. Lichenoid (interface) inflammatory infiltrate of lymphocytes and histiocytes, some lymphocytes are within the basal epidermis (H&E, x400) |
![](image/10.5923.s.health.201501.05_003.gif) | Figure 3. Basal epidermal damage has led to focal subepidermal cleft. A deep component to the inflammatory infiltrate can also be seen (H&E, x200) |
![](image/10.5923.s.health.201501.05_004.gif) | Figure 4. Scanning power of skin biopsy reveals the lobular arrangement of inflammatory cells at the deep aspect – corresponding to perieccrine involvement – a good clue at low power (H&E, x25) |
![](image/10.5923.s.health.201501.05_005.gif) | Figure 5. Accentuation of inflammatory infiltrate around eccrine glands (H&E, x400) |
3. Discussion
Lichen striatus (LS) is a self-limiting, acquired linear inflammatory dermatosis that is seen primarily in children and is uncommon in adults. The aetiology is unknown although there is an association with personal or family history of atopy. Certain triggering factors have been identified including infections, vaccines, pregnancy (as in the case of our patient), stress, drugs, skin trauma, and contact dermatitis [2, 8, 9, 10].Lesions begin as small (1-5mm) erythematous slightly scaly papules which form an interrupted or continuous line usually on the extremity or around the trunk following Blaschko's lines. Involvement of the chest or face (present case) is unusual. LS lesions are usually asymptomatic but when occuring in adults tend to be extensive and itchy [2, 11], sometimes requiring symptomatic treatment. The usual natural course is spontaneous resolution within 12 months. Nail involvement can occur including nail plate thinning, longitudinal ridging, splitting, and nail bed hyperkeratosis.The differential diagnosis of an acquired dermatosis in linear configuration includes linear lichen planus, linear morphea, inflammatory linear verucous dermatosis, linear epidermal naevus, inflammatory linear verrucous epidermal naevus, linear psoriasis, linear Darier’s disease, and incontinentia pigmenti [12]. Histopathological examination is therefore required and will provide a firm diagnosis in conjunction with the clinical features. Histopathology of LS reveals a predominantly lichenoid (interface) lymphohistiocytic infiltrate with a variable (absent to significant) degree of spongiotic dermatitis in addition. There is often hyperkeratosis and focal parakeratosis. On account of the interface dermatitis and subsequent basal epidermal damage with apoptotic cells and melanin incontinence, the features may closely resemble those of lichen planus. A striking additional feature in lichen striatus is a deep component to the inflammatory infiltrate centered around the deep dermal vascular plexus and adnexae especially perieccrine gland involvement [2, 12]. This latter feature is a helpful pointer to the diagnosis, as it was in the current case. Spongiosis (intercellular epidermal oedema) is often seen in biopsies of lichen striatus, and sometimes microvesicles containing Langerhan’s cells are formed. Sometimes spongiosis predominates over lichenoid inflammation, as for example in the rare entity adult blaschkitis. Adult blaschkitis is a term introduced in 1990 by Grosshans and Marot [13] to describe an acquired inflammatory linear eruption in adults consisting of pruritic papules and vesicular eruptions along the lines of Blaschko. It is regarded as a variant of lichen striatus and, apart from the mainly spongiotic histological pattern, differs from classical lichen striatus in its quick resolution and frequent recurrence.The treatment of LS includes topical steroids and in recent times immune modulator drugs such as the calcineurin inhibitors tacrolimus and pimecrolimus have shown efficacy in this setting [2, 14-15].
4. Conclusions
Although lichen striatus usually presents on the limbs of children and adolescents, it can uncommonly be seen in adults on sites other than the limbs, for example the face, as our case demonstrates. Lichen striatus should be considered in the differential diagnosis of any linear acquired inflammatory dermatosis irrespective of the patient’s age or site of involvement. Furthermore, histological features very often help provide a definitive diagnosis, and so biopsy is recommended.
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