Research in Neuroscience
p-ISSN: 2326-1226 e-ISSN: 2326-1234
2017; 6(1): 1-4
doi:10.5923/j.neuroscience.20170601.01
Koofreh G. Davies1, Innocent A. Edagha2
1Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
2Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
Correspondence to: Koofreh G. Davies, Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Nigeria.
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Copyright © 2017 Scientific & Academic Publishing. All Rights Reserved.
This work is licensed under the Creative Commons Attribution International License (CC BY).
http://creativecommons.org/licenses/by/4.0/
Despite the widespread use of Artemisinin combination therapies in the treatment of malaria, there is no available study on the effect of these anti-malarials on neurobehaviour. This study was therefore designed to investigate effects ACTs on anxiety T-Maze and cognition. Twenty five female albino mice weighing 20-26 g were used for this study. Animals were acclimatized and randomly selected into five groups. Light and Dark Box was used to test for anxiety while cognition was tested for with T-maze. Result showed no derangement in any of the neurobehavioural parameters tested for. This result indicates that malaria infection may not affect anxiety and cognition in subjects who currently on prophylactic ACTs. Also, Dihydroartemisinin/Piperaquine, Artemether/Lumefantrine and Artesunate/Amodiaquine did not affect cognition and anxiety at clinical dosage.
Keywords: Artemisinin-Combination Therapy, Prophylaxis, Plasmodium berghei, Anxiety, Cognition
Cite this paper: Koofreh G. Davies, Innocent A. Edagha, Neurobehavioural Effects of Some Artemisinin-Combination Therapies in Prophylactic Murine Malaria Model, Research in Neuroscience , Vol. 6 No. 1, 2017, pp. 1-4. doi: 10.5923/j.neuroscience.20170601.01.
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