Research in Neuroscience
p-ISSN: 2326-1226 e-ISSN: 2326-1234
2013; 2(2): 24-29
doi:10.5923/j.neuroscience.20130202.02
Mohamed M. Montasr1, Fady E. Aziz2, Dina Ahmed3
1Faculty of Medicine, Tanta University, Tanta, Egypt
2Faculty of Medicine, Cairo University, Cairo, Egypt
3Faculty of Medicine, Ain Shams University, Cairo, Egypt
Correspondence to: Mohamed M. Montasr, Faculty of Medicine, Tanta University, Tanta, Egypt.
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In our era of technology and progress in medical molecular biological science, it’s now obligatory to think extraordinary to deal with the brain tumors, reaching the best prognosis for a better outcome. We focused on proving the strong relation between the subtypes of medulloblastoma and the magnificent rule of B-catan in nucleo-positivity in a Wnt/ wg pathway, associated with mutations like APC, CTNNB1 as a good diagnosis and prognosis of Medulloblastoma, It’s mandatory applying these good prognostic factors in the prospective plan of treatment, using these factors like B-catenin nucleo-positivity in Wnt pathway subtype of medulloblastoma to reduce the dose of adjuvant therapy as radiotherapy and chemotherapy to reach a better result after management and to minimize the side effects of adjuvant therapy either chemotherapy or radiotherapy. In this manuscript we consider the past studies done from 2005 till 2012; talking about nucleo-positivity of B-catenin protein in medulloblastoma and the effect of it on prognosis, although the number of cases in these studies was not quite enough, but we can consider at least there is an evidence of association between positive B-catanin activity,Wnt/ wg pathway and good prognosis also for more specific approaches of treatment.
Keywords: Medulloblastoma, B-catenin, WNT Pathway, Improved Outcome, Prognostic Factor, Radiotherapy, Craniospinal Irradiation CSI
Cite this paper: Mohamed M. Montasr, Fady E. Aziz, Dina Ahmed, Β-Catenin Expression in Medulloblastoma: Prognosis and Favorable Outcome, Research in Neuroscience , Vol. 2 No. 2, 2013, pp. 24-29. doi: 10.5923/j.neuroscience.20130202.02.