International Journal of Diabetes Research
p-ISSN: 2163-1638 e-ISSN: 2163-1646
2017; 6(2): 35-40
doi:10.5923/j.diabetes.20170602.01
Aldeam Facey1, Lowell Dilworth2, Rosemarie Wright-Pascoe3, Melissa Walker4, Rachael Irving1
1The Department of Basic Medical Sciences, University of the West Indies, Mona
2The Department of Pathology, University of the West Indies, Mona
3Department of Medicine, University Hospital of the West Indies, Mona
4School of Nursing, University of the West Indies, Mona
Correspondence to: Aldeam Facey, The Department of Basic Medical Sciences, University of the West Indies, Mona.
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Diabetes mellitus, the metabolic disease which affects millions is increasing in prevalence. Type 2 diabetes mellitus results from genetic predisposition and lifestyle. Physically fit individuals such as athletes, even with a genetic predisposition tend to have a low incidence of type 2 diabetes mellitus. Several metabolites are associated with the disease and can provide insights regarding its development. The study sought to determine the association between type 2 diabetes mellitus and the metabolic hormones: leptin, adiponectin and troponin and to evaluate these hormones in athletes. Individuals ranging from 18 to 50 years of age were screened for diabetes using fasting glucose and HbA1c. Participants were classified into 6 groups: male athletes (MA), female athletes (FA), male diabetes patients (MD), female diabetes patients (FD), male controls (MC), female controls (FC). Leptin, adiponectin and troponin were determined for each group. Leptin levels were significantly higher in MD and FD while adiponectin was significantly lower in MD and FD. Skeletal muscle troponin T was not significantly different among the groups studied. Adiponectin and leptin may be used to distinguish between persons with diabetes and normoglycemia however levels of physical activity may not result in higher adiponectin concentration or lower leptin concentration in the non-diabetes state.
Keywords: Diabetes Mellitus, Leptin, Troponin T, Adiponectin, Athletes
Cite this paper: Aldeam Facey, Lowell Dilworth, Rosemarie Wright-Pascoe, Melissa Walker, Rachael Irving, The Metabolic Hormones Leptin, Adiponectin and Troponin T in Type 2 Diabetes Patients and Athletes in Jamaica, International Journal of Diabetes Research, Vol. 6 No. 2, 2017, pp. 35-40. doi: 10.5923/j.diabetes.20170602.01.
Table 1. Comparisons of anthropometrical characteristics among the groups |
Table 2. Significant differences in anthropometrical characteristics among the groups. P≤0.05 is significant |
Figure 3. A comparison of skeletal muscle troponin T concentrations among the diabetes patients, athletic and control groups. No significant differences were noted across the groups (P>0.05) |
Figure 5. A comparison of HbA1c concentrations among the diabetes, athletic and control groups. HbA1c is significantly higher (P<0.05) in the diabetes patients (MD, FD) |