International Journal of Control Science and Engineering
p-ISSN: 2168-4952 e-ISSN: 2168-4960
2017; 7(1): 11-17
doi:10.5923/j.control.20170701.02
Ying Shang, Adetola Oke
Department of Electrical and Computer Engineering, Southern Illinois University Edwardsville, Edwardsville, USA
Correspondence to: Ying Shang, Department of Electrical and Computer Engineering, Southern Illinois University Edwardsville, Edwardsville, USA.
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This work is licensed under the Creative Commons Attribution International License (CC BY).
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This paper presents a prefilter solution to the model reference control in high throughput screening in drug discovery, an automatic compound screening and analyzing process in pharmaceutical industries. Such a prefilter will generate an optimal scheduling despites of the system malfunctions and delays. The approach used in this paper is the max-plus linear system modelling and control in discrete-event systems. The main results are illustrated using enzyme screening compound screening applications.
Keywords: High-throughput screening systems, Discrete-event systems, Max-plus linear systems
Cite this paper: Ying Shang, Adetola Oke, Optimal Scheduling and Control of High Throughput Screening Systems using Max-plus Linear Systems, International Journal of Control Science and Engineering, Vol. 7 No. 1, 2017, pp. 11-17. doi: 10.5923/j.control.20170701.02.
Figure 1. Drug discovery process flowchart |
Figure 2. An example of transporting a microplate to the incubator for an HTS system (top) and its corresponding discrete-event system model (bottom) |
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Figure 3. HTS workflow for the enzyme screening |
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Figure 4. Model reference control in max-plus systems [19] |
Figure 5. Timed-event graph model for the HTS system with prefilter |