**Ratan Kumar Sarkar**

Janhavi, Keota, Hooghly, West Bengal, India

Correspondence to: Ratan Kumar Sarkar, Janhavi, Keota, Hooghly, West Bengal, India.

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Copyright © 2022 The Author(s). Published by Scientific & Academic Publishing.

This work is licensed under the Creative Commons Attribution International License (CC BY).

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**Abstract**

Stem cell biochemistry has been discussed in tyr-cys-gly complex that lies into fundamental molecular structure 238^{+}.3059^{-}(161^{+}) with its extended interface. The STF^{248} and STF^{220} are two anti-parallel human stem cell factors where hydrophobic domain is interrelated to deleted segment of stem cell factor that linked to lunar gravity. The complex shows opposite direction of time and the cleavage site would be the conflicts of electro-gravitational structure. The interception of molecular values of lunar gravity would be a process to combat cancer needing highly experimentation.

**Keywords: **
Stem cell factor, Reverse transcription, Hydro-phobic domain, Phosphorylation, Cysteine bond

**Cite this paper:** Ratan Kumar Sarkar, The Tyr-Cys-Gly Complex in Stem Cell Biochemistry, *American Journal of Chemistry*, Vol. 12 No. 3, 2022, pp. 51-53. doi: 10.5923/j.chemistry.20221203.01.

### 1. Introduction

Tyrosine (181.1894) is a curious amino acid of which gravitational time (181) is two step down (0.0038 or 2) of lunar time (183 = 0.3477) shows the opposite direction of time. Cystine (121.1590) is closely related to tyrosine since 0.1894 – 0.1590 = 0.0304 (oxy-time) and 181 – 121 = 60 and also 242 (cysteine pair) – 181 = 61. The fundamental molecular structure 238^{+}.3059^{-}(161^{+}) [1] is applicable while it is associated with stem cell biology. It was previously discussed 0.3477 – 0.3059 = 0.0418(22), 0.3667(193) – 0.3059 = 0.0608 (oxy-time) and 0.3667 – 0.3477 = 0.0190(10) in the structure. During replication while the system reaches at 0.3477 and correspondingly reaches at 0.0367 earth-moon curvature of time and bisects to 183*2 = 366 and 193 or 0.3667 also a point of bisection. Previously I have discussed [2], proline-genetic relations where 333 (CCC) + 154 = 487 (tri-de-oxy-nucleotide avg. MW) and 333 (CCC) – 6 = 327 (mono-de-oxy-nucleotide avg. MW) where 154 and 6 are factors of opposite in upper (+) and lower (-) level. The core values of proline (115.1311) = 115*0.0019 – 0.1311 = 0.0874 and pre-transitional values 0.1311 – 0.0115 = 0.1196 = 0.1605 (lunar gravity) - 0.0409 where 574 – 409 = 165 (cleavage site in STF^{248}) and also 575 + 154 = 729 are important.The gravitational and electro-magnetic difference 0.3477 – 2*0.1451 = 0.0575 = 575 is a structural parameter. The opposite values of 575 would be dimensionally 0.1963 while the opposite values of 0.1451 is 425. There is intrinsic structural values ‘1000’ gives 0.1000 – 0.0963 = 0.0037 and correspondingly 575*2 = 1150 shows 1000 – 150 = 850 and 850*2 = 1700 = 1738 (halved of lunar time) – 38 with 0.0001 or 1 time difference in the structure.The mass of proton = 938.2900 Mev/c^{2} and that of electron = 0.511Mev/c^{2} gives a structural conformation with 0.0002 time difference and one step decimal change.The core values or hidden time of glycine (75.0669) = 75*0.0019 – 0.0669 = 0.0756 and pre-transitional values = 0.0669 – 0.0075 = 0.0594 = 0.1605 (lunar gravity) – 0.1011. It is seen 756 – 594 = 162 (i.e. 0.3059 + 0.0019) and correspondingly 0.1011 – 0.0594 = 0.0417 = 0.0418 – 0.0001 where 0.3477 – 0.3059 = 0.0418 in the structure. Glycine is such a bio-product where time has been converted to opposite direction from 0.3059 to ‘161’ with 0.0001 or 0.0019 time difference and 0.3667 – 0.0669 = 0.2998 = 0.3059 – 0.0061 shows a difference of ‘100’ with respect to oxy-time.We can evaluate the length of stem cell factor (STF) from glycine where 669 + 248*2 = 1165 and 220*2 – 75 = 365 where 365 + 38 = 403 (hydrophobic domain) and 0.1165 + 0.1894 = 0.3059(161) and correspondingly 0.1894 – 0.1165 = 0.0729 = 0.0326 (deleted segment of STF^{220}) + 0.0403 (hydrophobic domain) in STF.It is seen 0.1894 – 0.1605 = 0.0289 = 289 and 0.1932 (i.e. 0.1894 + 0.0038) – 0.1605 = 0.0327= 327 (mono de-oxy-nucleotide average mw: 327g/mol) where 289 + 113 (6, factor of opposite) = 402 (i.e. 190 +212 = 402, hydro-phobic domain) = 487 (tri-de-oxy-nucleotide average mw: 487 g/mol) – 85 where 85 = 240 – 155 (factor of opposite) and correspondingly 969 – 240 = 729 where 969 = 418(22) + 551(29), intrinsic values in the structure.Decimals have been avoided somewhere while 0.0425 can transits to 425 and amino acid anti-gravitational time (e.g. 0.1849 for tyr) may be assumed as horizontal time (ht). A time difference of 0.0001-0.0002 is about common in the system.

### 2. Discussions

Stem cell factor is a hematopoietic cytokine, a glycosylated protein. Human stem cell factors STF^{248} and STF^{220} are originated from exon-6 having opposite directions where 402 – 154 = 248 and 327 + 113(6) = 440 and bisected. In STF structure the hydrophobic domain (190-212) and deleted amino acids (149-177) segment are interrelated. The deleted segment, 149 + 177 = 326 while hydrophobic domain, 190 + 212 = 402 = 487 – 85 (i.e. 0.1615, trp core values) and 85 is sub-divided as 85 = 62 + 23 to complement the structure while 85 + 155 (factor of opposite) = 240 = 969 – 729. Intrinsically, 969 = 418(22) + 551(29) where 212 – 190 = 22 and 177 – 149 = 29 with initiation point where 1605 (lunar gravity) + 364 = 1969 in the structure. Derived from tyrosine 1894 (ht) + 1165 = 3059(161) while 1894 – 1165 = 729 = 575 + 154 (factor of opposite) = 364*2 (app.), a structural shift from proline structural values 333(CCC) + 31 = 364. It is seen 1932 - 1605 = 327 (mono-de-oxy-nucleotide avg. MW) where 1932 – 1894 = 38 and 1894 – 1605 = 289 = 402 – 113 (6, factor of opposite) where 364 + 38 = 402 = 487 (tri-de-oxy-nucleotide avg. MW) – 85. The complementation of 85 = 23 + 62 would be 814 (i.e. 487 + 327) – 791 = 23 where 814 + 791 = 1605 (lunar gravity) and 1031 – 969 = 62 where ‘1000’ is a structural factor and 1606 – 1031 = 575 = 0.0575 = 0.3477(183) – 0.2902 (i.e. 0.1451*2), the electro-magnetic and gravitational difference in the structure.The deleted segment is replaced by glycine residue where 75.0669 + 89.0935(cleavage site, 165) = 164.1604 or 165. 1605. We can interpret STF elongation from glycine (75.0669) where 688 = 440 + 248 and 364 +76 = 440 by one step-up 0.0019 or 1 in both sides. It is seen 669 + 154 (factor of opposite) = 823 = 1425(75) – 602 where 602 + 220 = 822 and 823 – 575 = 248.The core values or hidden time of glycine = 75*0.0019 – 0.0669 = 0.0756 or 0.1244 where 0.1000 (a structural factor) – 0.0244 = 0.0756 in the structure and the values 0.0729 can be subdivided as 0.0729 = 729 = 327 + 402 = 289 + 440 in the molecular structure. The pre-transitional values of glycine = 0.0669 – 0.0075 = 0.0594 = 0.1605 - 0.1011 where 0.0593 = 0.0168 (tyr resultant value) + 0.0425 (opposite values of 0.1451) while 0.3059 = 0.1451 + 0.1608 that shows 165.1605 is a significant values possesses core values 0.1530 (i.e. about halved of 0.3059). The cleavage site (165) in STF^{248} would be a contradictory site of electro-gravity where 1605 – 165 = 1440 = 1031 + 409 (proline pre-transitional values measured from lunar gravity) and 1196 (proline pre-transitional values) – 1031 = 165 in the biochemical complex.In glycine 0.3059 transit to opposite side 161 where 756 – 594 = 161 + 1 and correspondingly 0.1011 – 0.0594 = 0.0417 = 0.0418 – 0.0001 where 0.3477(183) - 0.3059 = 0.0418. Now, 183 – 161 = 22(0.0418) = 212 – 190 (hydrophobic domain) and in opposite direction 402 – 344 = 58 = 0.1102 = 0.1605 – 0.0503 where 503 + 165 (cleavage site) = 668 and 1425(75) + 165 = 1590 (cys ht) in the complex.While opposite direction of time is a matter of stem cell factor, histidine (155.1552) is linked to the system. The pre-transitional values of his = 0.1552 – 0.0155 = 0.1397 = 0.1605 – 0.0208. In tyr-his complex, the pre-transitional values of tyr = 0.1894 – 0.0181 = 0.1713 = 0.1605 + 0.0108 and 208 + 108 = 316 = 326 – 10(0.0190) since tyr exists in upper level from lunar gravity shows 0.3667 – 0.3477 = 0.0190(10) is associated.In opposite direction, 0.1605 – 0.1393 (his core values) = 0.0212 = 212 = (0.3477 + 0.0402) – 0.3667(193) while 212 + 154 (factor of opposite) = 366 (or 0.0366 earth-moon curvature of time) aligned to 0.3477 and bisected to 183 + 209 = 392 = 402 – 10.Conversely, 0.3477 – 0.0326 = 0.3151 = 0.1606 + 0.1545 (tyr core values) where 0.3667 – 0.3151 = 0.0516 = 516 where 516 + 212 = 728 and 516 – 190 = 326 and also 516 – 212 = 304 (oxy-time) where 516 + 153 = 669 (gly ht) and 516 -153 = 363 in the structure.In context of tyr-cys complex, 0.1583 (i.e. 0.1545 + 0.0038) – 0.1418 (cys core values*2) = 165 (cleavage site) where 0.1605 – 0.1583 = 0.0022 = 22(0.0418) where 0.1894 – 0.0418 = 0.1476 = 0.3059 – 0.1583 in the structure. The values 85(0.1615, gravity in earth-moon context) is core values of tryptophan and 85 turned into opposite direction in STF while 402 = 487 – 85 and 242 + 85 = 327, a cys-trp complex is relevant. It is seen 0.3667 – 0.3477 = 0.0190(10) and 0.3667 – 0.2058 (trp pre-transitional values) = 0.1609 = 0.1615 – 0.0006 and conversely 85 + 6 = 91 (trp position in p53). The four cys residues in STF structure are cys138-cys43 and cys89-cys4 are intra-molecular disulphide pairs can be clarified as 89 + 4 = 93 = 154 – 61 where 242 - (138 + 43) = 61 and 272 + 181 = 453 (pre-transitional values of trp measured from lunar gravity i.e. 0.2058 – 0.1605 = 0.0453) and also 242 – 181 = 61 = 146 (trp position in p53) – 85. The molecular point ‘138’ would be significant for bio-activity is aligned to ‘61’ for fundamental molecular structure. The two cysteine (121.1590) values 136*2 (derived from lunar gravity) and 121*2 = 242 would exists in opposite direction where 272 -242 = 30 = 32(0.0608) – 2(0.0038, a significant values) and conversely 272 + 242 = 514 = 608 – 94. Lunar gravity and protein phosphorylation:The phosphate group PO_{4}^{3-} having molecular weight 94.9714g/mol. The phosphorylation of tyr/ser/thr gives molecular weights 276.1608/200.0614/214.0911 respectively where 0.0911 + 0.0697 = 0.1608 where 0.0911 – 0.0214 = 0.0697 and are interrelated. In cys-his complex, 121.1590 + 155.1552 = 276.3142 is comparable to 276.1608 where 276 = 138*2 and 0.3142 – 0.1608 = 0.1534 (or, 0.0466) = 767*2 where 767 – 403 = 364 = 1131 – 767 and 767 + 392 (i.e. 0.1608) = 0.1159(61) and also 425 – 276 = 149 = 155 (factor of opposite^{-}) – 6 (factor of opposite^{+}) while 0.3059(161) = 0.1608 + 0.1451.The core values of 200.614 = 0.3186 = 0.1932 (proportionate ht for 183) + 0.1254(66) where 0.1932 – 0.1254 = 0.0678 = 0.0351 + 0.0327 based on lunar gravity. Correspondingly 487 – 351 = 136 = 291 – 155 (factor of opposite) where 0.1545 (tyr core values) – 0.1254 = 0.0291 = 0.0392 (i.e. 0.1608) – 0.0100 approximately in the structure.Again, 276.1608 – 200.0614 = 76.0994 where 0.0994 – 0.0669 (gly ht) = 0.0325 = 325 = 425 (opposite values of electromagnetic 0.1451) – 100 causes difference of 100 that would actuates influx of electro-gravitational values. Alternatively, (0.1608 + 0.0614) – 0.0669 = 0.1553 (his ht where 0.0001 has been complemented).The values 276.1608 is associated with electromagnetic structure, 0.1608 + 0.1451 = 0.3059(161) while 238 – 183 = 55 = 155 – 100 in the structure.The values 0.1608 are significant for bio-activity as it covers a crucial relation among lunar time-lunar gravity-oxy-time and directional electro-gravitational chemistry that would be actuates influx of electro-gravitational impulses into the cell. The molecular values of lunar gravity would be a key factor to combat with cancer to intercept the influx provided highly experimentation.

### 3. Conclusions

The STF^{248} and STF^{220} are two anti-parallel stem cell factors that are aligned to fundamental molecular structure with its extended interface. The hydrophobic domain and deleted segment of STF are interrelated and linked to lunar gravity. Glycine shows opposite direction of time in tyrosine-cysteine complex. The molecular values of lunar gravity (0.1605) would be a key-point towards cancer remedy that needing highly experimentation.

###
References

[1] | Sarkar R. K., American Journal of Biochemistry 2020, 10(1): 5-8. |

[2] | Sarkar R. K., American Journal of Biochemistry 2022, 12(1): 4-7. |