[1] | Ho RH, Kim RB. 2005. Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther. 78:260–77. |
[2] | Sharom FJ. 2008. ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics 9:105–27. |
[3] | Anne L, Cécile M, Catherine B, Roger K. PrichardbaI N, 2011. P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance. Australian Society for Parasitology. Published by Elsevier Ltd. doi:10.1016/j.ijpddr. |
[4] | Vlaming M.L, Lagas J. S, Schinkel, A.H, 2009. Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knock out mice. A dvanced drug delivery reviews. 61(1): 14–25. Epub .doi:10.1016/j.addr. |
[5] | Ito N, Ito K, Ikebuchi Y, Kito T, Miyata H, Toyoda Y, et al. 2014 .Organic cation transporter/solute carrier family 22a is involved in drug transfer in to milk in mice. Journal of pharmaceutical sciences. 103 (10): 3342–8. Epub 2014/09/02. Doi: 10. 1002 /jps. 24138 PMID: 25175747. |
[6] | Jan A. S and Johanna F.G.2008. Implications of ABC transporters on the disposition of typical veterinary medicinal products. European Journal of Pharmacology. 585: 510–519. doi:10.1016/j.ejphar. |
[7] | Marzolini C, Paus E, Buclin T, Kim RB. 2004. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 75: 13–33. |
[8] | Choudhuri S, Klaassen CD. 2006. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol 25: 231–59. |
[9] | Leslie EM, Deeley RG, Cole SP. 2005. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204: 216–37. |
[10] | Hoffmeyer S, Burk O, Von Richter O, Arnold HP, Brockmoller J, Johne A, et al. 2000. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 97: 3473–8. |
[11] | Moriya Y, Nakamura T, Horinouchi M, Sakaeda T, Tamura T, Aoyama N, et al.2005. Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects. Biol Pharm Bull. 25: 1356–9. |
[12] | Roulet A, Puel O, Gesta S, Lepage JF, Drag M, Soll M, Alvinerie M, Pineau T. 2003. MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur J Pharmacol. 460:85–91. [PubMed: 12559367]. |
[13] | Lankas GR, Cartwright ME, Umbenhauer D. 1997. P-glycoprotein deficiency in a subpopulation of CF-1mice enhances avermectin-induced neurotoxicity. Toxicol Appl Pharmacol.143:357–365. [PubMed: 9144452]. |
[14] | Kwei GY, Alvaro RF, Chen Q, Jenkins HJ, Hop CE, Keohane CA, Ly VT, Strauss JR, Wang RW, Wang Z, Pippert TR, Umbenhauer DR. 1992. Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein. Drug Metab Dispos 27:581–587. [PubMed: 10220486]. |
[15] | Wang Z, Sew PH, Ambrose H, Ryan S, Chong SS, Lee EJ, et al. 2006. Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region. BMC Genomics.7:111. |
[16] | Fukushima-Uesaka H, Saito Y, Tohkin M, Maekawa K, Hasegawa R, Kawamoto M, et al. 2007. Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population. Drug Metab Pharmacokinet 22: 48–60. |
[17] | Conrad S, Kauffmann H-M, Ito K-I, Deeley RG, Cole SP, Schrenk D. 2001. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671 V substitution. J Hum Genet; 46:656–63. |
[18] | Letourneau IJ, Deeley RG, Cole SP. 2005. Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1). Pharmacogenet Genomics 15: 647–57. |
[19] | Pawlowski, K.M.; Mucha, J.; Majchrzak, K.; Motyl, T.; Krol, M. 2013. Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells. BMC Vet. Res. 9, doi:10.1186/1746-6148-9-119. |
[20] | Honscha, K.U.; Schirmer, A.; Reischauer, A.; Schoon, H.A.; Einspanier, A.; Gabel, G. 2009. Expression of ABC-transport proteins in canine mammary cancer: Consequences for chemotherapy. Reprod. Domest. Anim., 44 (Suppl 2), 218–223. |
[21] | YIN, J and ZHANG,J,. 2011. Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application. NIH-PA Author Manuscript. 36(10): 927–938, doi: 10.3969/j.issn. |
[22] | Ng, P.C, and Henikoff, S. 2003. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 31: 3812–3814. |
[23] | Alencar S. A, and Julio C.D, 2010. A Comprehensive In Silico Analysis of the Functional and Structural Impact of SNPs in the IGF1R Gene. Journal of Biomedicine and Biotechnology. 8 pages. doi:10.1155.715139. |
[24] | Choi Y, Sims GE, Murphy S, Miller JR, Chan AP, 2012. Predicting the functional effect of amino acid substitutions and indels. PLoS One; 7(10): e46688. |
[25] | Raman, Th and Jata, Sh,. 2016. In silico Analysis Revealed High-risk Single Nucleotide Polymorphisms in Human Pentraxin-3 Gene and their Impact on Innate Immune Response against Microbial Pathogens. Microbial Immunology, a section of the journal Frontiers in Microbiology. 2016 doi: 10.3389/fmicb.2016.00192. |
[26] | Calabrese R., Capriotti. E, Fariselli. P, Martelli. P. L, Casadio. R. 2009. Functional Annotations Improve the Predictive Score of Human Disease-related Mutations in Proteins. Human Mutation. 30: 1237-1244. doi: 10.1002/humu.21047. |
[27] | Nahla, E. A, Ghada, M. El, Lamia, O. O, Samar, A. A, Aisha, S. A, Ahmed, H. El, and Sofia, B. M. 2016. A Comprehensive in Silico Analysis of the Functional and Structural Impact of Non-Synonymous Single Nucleotide Polymorphisms in the Human KRAS Gene. American Journal of Bioinformatics Research. 6: 32-55 DOI: 10.5923/j.bioinformatics.20160602.02. |
[28] | Christian J. A. Sigrist, Lorenzo Cerutti, Edouard de Castro, Petra S. Langendijk-Genevaux, Virginie Bulliard, Amos Bairoch and Nicolas Hulo 2010. PROSITE, a protein domain database for functional characterization and annotation. Nucleic Acids Research. 38: 161–166 doi:10.1093/nar/gkp885. |
[29] | Radivojac, P, Vacic, V, Haynes C, Cocklin, R.R, Mohan, A, et al. 2010. Identification, analysis, and prediction of protein ubiquitination sites. Proteins. 78: 365–380. doi: 10.1002/prot.22555. |
[30] | Gill G,. 2003. Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity. Curr Opin Genet Dev. 13: 108–113. PMID: 12672486. |
[31] | Blom, N, Gammeltoft, S, Brunak, L,. 1999. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 294: 1351– 1362. PMID: 10600390. |
[32] | Arriagada G, Muntean, L.N and Goff, S.P,. 2011. SUMO-interacting motifs of human TRIM5a are important for antiviral activity. PLoS Pathog. 7: e1002019. doi: 0.1371/journal.ppat.1002019. |
[33] | Wenzhong, L, Yubin, X, Jiyong, M, Xiaotong, L, Peng, N, Zhixiang, Z, Urs, L, Qi, Z, Yueyuan, Z, Yong Z, Yu Xue and Jian, R, 2015. IBS: an illustrator for the presentation and visualization of biological sequences. Bioinformatics 1–3. doi: 10.1093/bioinformatics/btv362. |
[34] | Sofia B. M and Mohamed M. H,. 2016. Insilico Validation of Babesia Bovis Merozoite Surface Antigen-1, Merozoite Surface Antigen-2b and Merozoite Surface Antigen-2c Proteins for Vaccine and Drug Development. International Journal of Bioinformatics and Biomedical Engineering. 2: 30-39. ISSN: 2381-7399 (Print); ISSN: 2381-7402 (Online). |
[35] | Nahla E. Abdelraheem, Ghada M. El-Tayeb, Lamia O. Osman, Samar A. Abedlrhman.. 2016. A Comprehensive in Silico Analysis of the Functional and Structural Impact of Non-Synonymous Single Nucleotide Polymorphisms in the Human KRAS Gene. American Journal of Bioinformatics Research. 6(2): 32-55 DOI: 10.5923/j.bioinformatics.20160602.02. |
[36] | Deveci M. Ümit V. C and Amanda E. T. 2014. mrSNP: Software to detect SNP effects on microRNA binding. BMC Bioinformatics. 15: 1471-2105. http://www.biomedcentral.com. |
[37] | Sauna ZE, Muller M, Peng XH, Ambudkar SV. 2002. Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human Pglycoprotein (ABCB1). Biochemistry 41:13989–14000. [PubMed: 12437356]. |
[38] | Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM. 1999. Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry 38:13887–13899. [PubMed: 10529234]. |
[39] | Loo TW, Bartlett MC, Clarke DM. 2004. Processing mutations located throughout the human multidrug resistance P-glycoprotein disrupt interactions between the nucleotide binding domains. J Biol Chem 279:38395–38401. [PubMed: 15247215]. |
[40] | Oselin K, Mrozikiewicz PM, Gaikovitch E, Pahkla R, Roots I. 2003. Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene. Eur J Clin Pharmacol .59:347–350. [PubMed: 12856092]. |
[41] | Shiloh, Y and Ziv, Y,. 2013. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 14: 197–210. PMID:23847781 |
[42] | Ashkenazy H, Erez E, Martz E, Pupko T, Ben-Tal N,. 2010. ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids. Nucleic Acids Res 38: W529–33. doi: 10.1093/nar/gkq399. |
[43] | Bourguignon, L.Y.; Spevak, C.C.; Wong, G.; Xia, W.; Gilad, E. 2009. Hyaluronan-CD44 interaction with protein kinase C (epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J. Biol. Chem. 284, 26533–26546. |
[44] | Zhu, X.; Li, Y.; Shen, H.; Li, H.; Long, L.; Hui, L.; Xu, W. MiR. 2013. restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1. Acta Biochim. Biophys. Sin. (Shanghai). 45: 80–86. |
[45] | Jaiswal, R.; Luk, F.; Gong, J.; Mathys, J.M.; Grau, G.E.; Bebawy, M. 2012. Microparticle conferred microRNA profiles—Implications in the transfer and dominance of cancer traits. Mol. Cancer. 11, doi:10.1186/1476-4598-11-37. |