American Journal of Organic Chemistry
p-ISSN: 2163-1271 e-ISSN: 2163-1301
2012; 2(1): 14-17
doi:10.5923/j.ajoc.20120201.03
Fouzia Bouchareb1, Sihem Hessainia1, Malika Berredjem1, Hounaida Benbouzid2, Houria Djebbar1, Nour-Eddine Aouf1
1Laboratory of Applied Organic Chemistry, Badji-Mokhtar University BP12. Annaba, 23000, Algeria
2Laboratory of Cell Toxicology, General Direction of Scientific Research and Technological Development, Algeria
Correspondence to: Malika Berredjem, Laboratory of Applied Organic Chemistry, Badji-Mokhtar University BP12. Annaba, 23000, Algeria.
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In this work, we described the synthesis of new heterocyclic organophosphorus compounds starting from a primary amine and phenyl phosphonic dichloride (PDCP). The introduction of a phosphoryl group into heterocyclic structures can generate potential chemical and biological activities. We have prepared the phosphoramidates in only one step. These compounds provide access to diazaphospholidine by intermolecular cyclization using dibromoethane. We chose primary amines (cyclohexylamine, benzylamine, propylamine and phenyl ethylamine) to prepare phosphoramidates. The toxicological activity of two synthesized molecules was evaluated.
Keywords: Phenyl Phosphonic Dichloride, Phosphoramidate, Diazaphospholidine
Cite this paper: Fouzia Bouchareb, Sihem Hessainia, Malika Berredjem, Hounaida Benbouzid, Houria Djebbar, Nour-Eddine Aouf, Efficient Method for the Synthesis of Diazaphospholidines: Toxicological Evaluation, American Journal of Organic Chemistry, Vol. 2 No. 1, 2012, pp. 14-17. doi: 10.5923/j.ajoc.20120201.03.
![]() | Scheme 1. |
![]() | Figure 1. Effects of the molecule (1a) on the respiratory metabolism |
![]() | Figure 2. Effects of the molecule (1b) on the respiratory metabolism |