American Journal of Biomedical Engineering
p-ISSN: 2163-1050 e-ISSN: 2163-1077
2012; 2(1): 17-23
doi: 10.5923/j.ajbe.20120201.03
S. H Sabzpoushan , Alireza Faghani Ghodrat
Department of Biomedical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
Correspondence to: Alireza Faghani Ghodrat , Department of Biomedical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran.
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Copyright © 2012 Scientific & Academic Publishing. All Rights Reserved.
Signal transmission in the form of propagating waves of electrical excitation is a fast type of communication and coordination between cells that is known in cardiac tissue as the action potential.In this article we used an efficient model of cardiac ventricular cell that is based on partial differential equations(PDE).After that a computational algorithm for action potential propagation was represented that according to this algorithm and proposed efficient model, We demonstrated action potential propagation in one-dimensional (1D) and two-dimensional (2D) space lattices using the central finite-difference method.In addition we investigated the effect of obstacles on the propagation of normal action potential using represented 2D excitable medium.Our results show that proposed efficient model, represented algorithm and excitable media are suitable for simulation of action potential propagation in cardiac tissue.
Keywords: Action potential propagation, Partial differential equation, Numerical method, Excitable media, Arrhythmia
Cite this paper: S. H Sabzpoushan , Alireza Faghani Ghodrat , "Simulation of Action Potential Propagation in Cardiac Ventricular Tissue Using an Efficient PDE Model", American Journal of Biomedical Engineering, Vol. 2 No. 1, 2012, pp. 17-23. doi: 10.5923/j.ajbe.20120201.03.
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Figure 1. Action potential of single cardiac cell(ventricle myocardial cell) |
Figure 2. The procedure of action potential propagation in one-dimensional(1D) state |
Figure 5. Effect of inexcitable obstacle as a dead tissue on the normal action potential propagation |